The Effect of Inhaled Salmeterol on Methacholine responsiveness in [email protected] with asthma up to 12 hours


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The Effect of inhaled salmeterol on methacholine responsiveness in [email protected] with asthma up to 12 hours is a well-researched topic, it is to be used as a guide or framework for your Academic Research.


The duration of the protective effect of 50 and 100 pg of inhaled salmeterol against methacholine-induced bronchoconstriction was compared with that of ;!OO pg of inhaled salbutamol in 12 patients with asthma with a baseline FEV, of at least 70% and a provocative
concentration of inhaled methacholine causing a 20% fall in FEV, (PC;,) %3 mglml. The study was placebo controlled, double blind, randomized, and crossover. The bronchodilating effect was no longer significant 4 hours after inhalation of salbutamol, whereas the effect was still
present 12 hours after administration of 50 and 100 pg of salmeterol. All active treatments caused PC,, to increase at 1 hour (p < 0.05). PC,, (milligrams per milliliter) thus reached 3.7 +- 0.8 after placebo, 13.8 -C 3.0 after 50 pg of salmeterol, 23.2 k 4.7 after 100 ~g of salmeterol, and 13.9 k 3.4 after 200 pg of salbutamol. The protective effect of 200 pg of
salbutamol was no longer sign&ant at 4 hours, whereas both doses C$ salmeterol protected against methacholine challenge up to 12 hours after inhalation (p < 0.01). An increased incidence of tremor (2112) and palpitations (2112) was recorded after inhalation of 100 pg of
salmeterol. We conclude that inhalation of 50 or 100 pg of salmeterol causes a long-lasting bronchodilatation and protects against methacholine-induced bronchoconstriction for at least 12 hours.


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Allergy and Clinical Immunology

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